| Pathway Id | ko00563 |
| Class & Sub-Class | Class: Metabolism Sub-Class: Glycan biosynthesis and metabolism |
| Description | Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure; characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane; (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER; and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis gene result in a genetic disorder; paroxysmal nocturnal hemoglobinuria. Source: KEGG Database |
Make changes to the option below (image Size) and click here to update the map:
| Image Size | You can change the size of an image just by changing the width or height attributes. Size (enter width only) the present size is: | |
| Get Data Out | |
| Click here to show selected items: | |